Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?

MANUSCRIPT NUMBER (JN-01216-2004.R1) FINAL ACCEPTED VERSION Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?

The predominant excitatory synaptic input to the hippocampus arises from entorhinal cortical axons that synapse with dentate granule cells, which in turn synapse with CA3 pyramidal cells. Thus, two highly excitable brain areas – the entorhinal cortex and the CA3 field – are separated by dentate granule cells, which have been proposed to function as a gate or filter. However, unlike rats, primat...

Effect of insulin and L-ascorbic acid on rate of neuronal apoptosis in dentate gyrus and CA3 region of hippocampus in type 1 diabetic rats

Introduction: The aim of this study was to determine the effects of Insulin and Lascorbic acid on prevention of neuronal in granular layer of dentate gyrus and pyramidal layer of CA3 of hippocampus in streptozotocin-Induced diabetic rats. Methods: In this experimental study, diabetes type 1 was included by a single intraperitoneal injection of streptozotocin (STZ) (60mg/kg) in male adult ...

Does a Unique Type of CA3 Pyramidal Cell in Primates

Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective Behavior Without Affecting Dentate Neurogenesis

Various growth factors regulate synapse development and neurogenesis, and are essential for brain function. Changes in growth factor signaling are implicated in many neuropsychiatric disorders such as depression, autism and epilepsy. We have previously identified that fibroblast growth factor 22 (FGF22) is critical for excitatory synapse formation in several brain regions including the hippocam...

Pii: S0306-4522(00)00146-9

The hippocampal mossy fiber pathway between the granule cells of the dentate gyrus and the pyramidal cells of area CA3 has been the target of numerous scientific studies. Initially, attention was focused on the mossy fiber to CA3 pyramidal cell synapse because it was suggested to be a model synapse for studying the basic properties of synaptic transmission in the CNS. However, the accumulated b...